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BMCBI
2010
14 years 9 months ago
2010
Background: Gene clustering for annotating gene functions is one of the fundamental issues in bioinformatics. The best clustering solution is often regularized by multiple constra...
93
Voted
BMCBI
2010
14 years 9 months ago
2010
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...
BMCBI
2010
14 years 9 months ago
2010
Background: For ecological studies, it is crucial to count on adequate descriptions of the environments and samples being studied. Such a description must be done in terms of thei...
90
Voted
BMCBI
2010
14 years 9 months ago
2010
Background: Phenomenological information about regulatory interactions is frequently available and can be readily converted to Boolean models. Fully quantitative models, on the ot...
BMCBI
2010
14 years 9 months ago
2010
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...