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BMCBI
2007
94views more  BMCBI 2007»
15 years 5 months ago
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays
Background: Affymetrix SNP arrays can interrogate thousands of SNPs at the same time. This allows us to look at the genomic content of cancer cells and to investigate the underlyi...
Philippe Lamy, Claus L. Andersen, Lars Dyrskjot, N...
BMCBI
2008
84views more  BMCBI 2008»
15 years 5 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
ENTCS
2008
103views more  ENTCS 2008»
15 years 5 months ago
Distributed Markovian Bisimulation Reduction aimed at CSL Model Checking
The verification of quantitative aspects like performance and dependability by means of model checking has become an important and vivid area of research over the past decade. An ...
Stefan Blom, Boudewijn R. Haverkort, Matthias Kunt...
BMCBI
2006
115views more  BMCBI 2006»
15 years 5 months ago
SimArray: a user-friendly and user-configurable microarray design tool
Background: Microarrays were first developed to assess gene expression but are now also used to map protein-binding sites and to assess allelic variation between individuals. Rega...
Richard P. Auburn, Roslin R. Russell, Bettina Fisc...
BMCBI
2006
125views more  BMCBI 2006»
15 years 5 months ago
Evaluating different methods of microarray data normalization
Background: With the development of DNA hybridization microarray technologies, nowadays it is possible to simultaneously assess the expression levels of thousands to tens of thous...
André Fujita, João Ricardo Sato, Leo...