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BIOCOMP
2006
14 years 10 months ago
Dynamic Bayesian Network (DBN) with Structure Expectation Maximization (SEM) for Modeling of Gene Network from Time Series Gene
Exploring gene regulatory network is a key topic in molecular biology. In this paper, we present a new dynamic Bayesian network (DBN) framework embedded with structural expectatio...
Yu Zhang, Zhidong Deng, Hongshan Jiang, Peifa Jia
KDD
2005
ACM
91views Data Mining» more  KDD 2005»
15 years 9 months ago
On mining cross-graph quasi-cliques
Joint mining of multiple data sets can often discover interesting, novel, and reliable patterns which cannot be obtained solely from any single source. For example, in cross-marke...
Jian Pei, Daxin Jiang, Aidong Zhang
BMCBI
2007
227views more  BMCBI 2007»
14 years 9 months ago
Growing functional modules from a seed protein via integration of protein interaction and gene expression data
Background: Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction (PPI) networks. A key concept in the o...
Ioannis A. Maraziotis, Konstantina Dimitrakopoulou...
RECOMB
2008
Springer
15 years 9 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
BIOINFORMATICS
2006
135views more  BIOINFORMATICS 2006»
14 years 9 months ago
Effective similarity measures for expression profiles
It is commonly accepted that genes with similar expression profiles are functionally related. However, there are many ways one can measure the similarity of expression profiles, a...
Golan Yona, William Dirks, Shafquat Rahman, David ...