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108
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BMCBI
2010
2010
On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence
15 years 1 months ago
Background: In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput gen...
116
Voted
BMCBI
2010
15 years 1 months ago
2010
Background: In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other high-throughput t...
107
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BMCBI
2010
15 years 1 months ago
2010
Background: Accurately covering the conformational space of amino acid side chains is essential for important applications such as protein design, docking and high resolution stru...
BMCBI
2010
15 years 1 months ago
2010
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
110
Voted
BMCBI
2010
15 years 1 months ago
2010
Background: One of the challenges of bioinformatics remains the recognition of short signal sequences in genomic DNA such as donor or acceptor splice sites, splicing enhancers or ...