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BMCBI
2010
103views more  BMCBI 2010»
14 years 12 months ago
Detecting internally symmetric protein structures
Background: Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. H...
Changhoon Kim, Jodi Basner, Byungkook Lee
BMCBI
2010
143views more  BMCBI 2010»
14 years 12 months ago
Learning gene regulatory networks from only positive and unlabeled data
Background: Recently, supervised learning methods have been exploited to reconstruct gene regulatory networks from gene expression data. The reconstruction of a network is modeled...
Luigi Cerulo, Charles Elkan, Michele Ceccarelli
BMCBI
2010
126views more  BMCBI 2010»
14 years 12 months ago
A boosting method for maximizing the partial area under the ROC curve
Background: The receiver operating characteristic (ROC) curve is a fundamental tool to assess the discriminant performance for not only a single marker but also a score function c...
Osamu Komori, Shinto Eguchi
BMCBI
2010
125views more  BMCBI 2010»
14 years 12 months ago
Large-scale prediction of protein-protein interactions from structures
Background: The prediction of protein-protein interactions is an important step toward the elucidation of protein functions and the understanding of the molecular mechanisms insid...
Martial Hue, Michael Riffle, Jean-Philippe Vert, W...
BMCBI
2010
113views more  BMCBI 2010»
14 years 12 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
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