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152
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BMCBI
2008
15 years 4 months ago
2008
Background: Functional annotation of proteins remains a challenging task. Currently the scientific literature serves as the main source for yet uncurated functional annotations, b...
137
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BMCBI
2008
15 years 4 months ago
2008
Background: In DNA microarray gene expression profiling studies, a fundamental task is to extract statistically significant genes that meet certain research hypothesis. Currently,...
121
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AI
2006
Springer
15 years 4 months ago
2006
Springer
In many situations, a set of hard constraints encodes the feasible configurations of some system or product over which multiple users have distinct preferences. However, making su...
138
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BMCBI
2006
15 years 4 months ago
2006
Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such...
139
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BMCBI
2006
15 years 4 months ago
2006
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...