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» Empirical Bayes analysis of single nucleotide polymorphisms
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BMCBI
2011
14 years 1 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu
RECOMB
2009
Springer
15 years 10 months ago
COE: A General Approach for Efficient Genome-Wide Two-Locus Epistasis Test in Disease Association Study
The availability of high density single nucleotide polymorphisms (SNPs) data has made genome-wide association study computationally challenging. Twolocus epistasis (gene-gene inter...
Xiang Zhang, Feng Pan, Yuying Xie, Fei Zou, Wei Wa...
ISBI
2011
IEEE
14 years 1 months ago
Principal components regression: Multivariate, gene-based tests in imaging genomics
In imaging genomics, there have been rapid advances in genome-wide, image-wide searches for genes that influence brain structure. Most efforts focus on univariate tests that treat...
Derrek P. Hibar, Jason L. Stein, Omid Kohannim, Ne...
ISBI
2011
IEEE
14 years 1 months ago
Hierarchical clustering of the genetic connectivity matrix reveals the network topology of gene action on brain microstructure:
Genetic correlation (rg) analysis determines how much of the correlation between two measures is due to common genetic influences. In an analysis of 4 Tesla diffusion tensor image...
Ming-Chang Chiang, Marina Barysheva, Katie McMahon...
BMCBI
2010
162views more  BMCBI 2010»
14 years 9 months ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...