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» Empirical Bayes analysis of single nucleotide polymorphisms
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BMCBI
2011
14 years 6 months ago
SNP-based pathway enrichment analysis for genome-wide association studies
Background: Recently we have witnessed a surge of interest in using genome-wide association studies (GWAS) to discover the genetic basis of complex diseases. Many genetic variatio...
Lingjie Weng, Fabio Macciardi, Aravind Subramanian...
BMCBI
2007
145views more  BMCBI 2007»
14 years 12 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2006
142views more  BMCBI 2006»
14 years 12 months ago
PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
Background: We present a general approach to perform association analyses in pedigrees of arbitrary size and structure, which also allows for a mixture of pedigree members and ind...
Kristina Allen-Brady, Jathine Wong, Nicola J. Camp
ICCAD
2003
IEEE
170views Hardware» more  ICCAD 2003»
15 years 8 months ago
Evaluation of Placement Techniques for DNA Probe Array Layout
DNA probe arrays have emerged as a core genomic technology that enables cost-effective gene expression monitoring, mutation detection, single nucleotide polymorphism analysis and ...
Andrew B. Kahng, Ion I. Mandoiu, Sherief Reda, Xu ...
BMCBI
2010
108views more  BMCBI 2010»
14 years 12 months ago
A genetic ensemble approach for gene-gene interaction identification
Background: It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases...
Pengyi Yang, Joshua W. K. Ho, Albert Y. Zomaya, Bi...