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» Estimation of the Rate-Distortion Function
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149
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BMCBI
2010
97views more  BMCBI 2010»
15 years 3 months ago
Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear a
Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Maris Lapinsh, Jarl E. S. Wikberg
125
Voted
BMCBI
2010
102views more  BMCBI 2010»
15 years 3 months ago
Alignment and clustering of phylogenetic markers - implications for microbial diversity studies
Background: Molecular studies of microbial diversity have provided many insights into the bacterial communities inhabiting the human body and the environment. A common first step ...
James Robert White, Saket Navlakha, Niranjan Nagar...
108
Voted
BMCBI
2010
89views more  BMCBI 2010»
15 years 3 months ago
Detection of gene pathways with predictive power for breast cancer prognosis
Background: Prognosis is of critical interest in breast cancer research. Biomedical studies suggest that genomic measurements may have independent predictive power for prognosis. ...
Shuangge Ma, Michael R. Kosorok
145
Voted
BMCBI
2010
176views more  BMCBI 2010»
15 years 3 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
129
Voted
BMCBI
2010
99views more  BMCBI 2010»
15 years 3 months ago
Shared probe design and existing microarray reanalysis using PICKY
Background: Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restriction...
Hui-Hsien Chou