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» Evolution of Biological Complexity
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BMCBI
2010
86views more  BMCBI 2010»
15 years 4 months ago
A novel approach to simulate gene-environment interactions in complex diseases
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with lar...
Roberto Amato, Michele Pinelli, Daniel D'Andrea, G...
BMCBI
2007
122views more  BMCBI 2007»
15 years 4 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
IWPEC
2010
Springer
15 years 2 months ago
On the Kernelization Complexity of Colorful Motifs
The Colorful Motif problem asks if, given a vertex-colored graph G, there exists a subset S of vertices of G such that the graph induced by G on S is connected and contains every c...
Abhimanyu M. Ambalath, Radheshyam Balasundaram, Ch...
KDD
2004
ACM
139views Data Mining» more  KDD 2004»
16 years 4 months ago
Learning a complex metabolomic dataset using random forests and support vector machines
Metabolomics is the omics science of biochemistry. The associated data include the quantitative measurements of all small molecule metabolites in a biological sample. These datase...
Young Truong, Xiaodong Lin, Chris Beecher
DNA
2009
Springer
173views Bioinformatics» more  DNA 2009»
15 years 10 months ago
Time-Complexity of Multilayered DNA Strand Displacement Circuits
Recently we have shown how molecular logic circuits with many components arranged in multiple layers can be built using DNA strand displacement reactions. The potential application...
Georg Seelig, David Soloveichik