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» Evolution of Biological Complexity
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BMCBI
2006
120views more  BMCBI 2006»
15 years 5 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
147
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BMCBI
2006
117views more  BMCBI 2006»
15 years 5 months ago
SigFlux: A novel network feature to evaluate the importance of proteins in signal transduction networks
Background: Measuring each protein's importance in signaling networks helps to identify the crucial proteins in a cellular process, find the fragile portion of the biology sy...
Wei Liu, Dong Li, Jiyang Zhang, Yunping Zhu, Fuchu...
BMCBI
2006
156views more  BMCBI 2006»
15 years 5 months ago
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...
NN
1998
Springer
151views Neural Networks» more  NN 1998»
15 years 4 months ago
Evolutionary neurocontrollers for autonomous mobile robots
In this article we describe a methodology for evolving neurocontrollers of autonomous mobile robots without human intervention. The presentation, which spans from technological an...
Dario Floreano, Francesco Mondada
RECOMB
2002
Springer
16 years 5 months ago
Inferring Piecewise Ancestral History from Haploid Sequences
There has been considerable recent interest in the use of haplotype structure to aid in the design and analysis of case-control association studies searching for genetic predictors...
Russell Schwartz, Andrew G. Clark, Sorin Istrail