2178 search results - page 222 / 436 » Evolution of Biological Complexity |
120
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BMCBI
2010
15 years 4 months ago
2010
Background: A protein binding hot spot is a small cluster of residues tightly packed at the center of the interface between two interacting proteins. Though a hot spot constitutes...
154
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BMCBI
2010
15 years 4 months ago
2010
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
136
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BMCBI
2010
15 years 4 months ago
2010
Background: Expression microarrays are increasingly used to obtain large scale transcriptomic information on a wide range of biological samples. Nevertheless, there is still much ...
131
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BMCBI
2010
15 years 4 months ago
2010
Background: Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predict...
148
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BMCBI
2010
15 years 4 months ago
2010
Background: Quantitative models for transcriptional regulation have shown great promise for advancing our understanding of the biological mechanisms underlying gene regulation. Ho...