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» Evolution of discrete gene regulatory models
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BMCBI
2008
118views more  BMCBI 2008»
13 years 6 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
GI
2009
Springer
13 years 11 months ago
Massively-Parallel Simulation of Biochemical Systems
: Understanding biological evolution prompts for a detailed understanding of the realized phenotype. Biochemical and gene regulatory dynamics are a cornerstone for the physiology o...
Jens Ackermann, Paul Baecher, Thorsten Franzel, Mi...
BMCBI
2006
87views more  BMCBI 2006»
13 years 6 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
CORR
2007
Springer
127views Education» more  CORR 2007»
13 years 6 months ago
Attribute Exploration of Discrete Temporal Transitions
Discrete temporal transitions occur in a variety of domains, but this work is mainly motivated by applications in molecular biology: explaining and analyzing observed transcriptome...
Johannes Wollbold
BMCBI
2008
172views more  BMCBI 2008»
13 years 6 months ago
Compo: composite motif discovery using discrete models
Background: Computational discovery of motifs in biomolecular sequences is an established field, with applications both in the discovery of functional sites in proteins and regula...
Geir Kjetil Sandve, Osman Abul, Finn Drablø...