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BMCBI
2007
106views more  BMCBI 2007»
13 years 6 months ago
Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive as
Background: A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with simila...
Raja Jothi, Teresa M. Przytycka, L. Aravind
CISIS
2009
IEEE
14 years 1 months ago
A Nonmonotonic Logical Approach for Modelling and Revising Metabolic Networks
—This paper describes a new logic-based approach for representing and reasoning about metabolic networks. First it shows how biological pathways can be elegantly represented in a...
Oliver Ray, Ken E. Whelan, Ross D. King
BMCBI
2010
86views more  BMCBI 2010»
13 years 6 months ago
Reaction graph kernels predict EC numbers of unknown enzymatic reactions in plant secondary metabolism
Background: Understanding of secondary metabolic pathway in plant is essential for finding druggable candidate enzymes. However, there are many enzymes whose functions are not yet...
Hiroto Saigo, Masahiro Hattori, Hisashi Kashima, K...
BMCBI
2005
149views more  BMCBI 2005»
13 years 6 months ago
The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional pre
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
Jan Kosinski, Marcin Feder, Janusz M. Bujnicki
BMCBI
2011
12 years 9 months ago
FFCA: a feasibility-based method for flux coupling analysis of metabolic networks
Background: Flux coupling analysis (FCA) is a useful method for finding dependencies between fluxes of a metabolic network at steady-state. FCA classifies reactions into subsets (...
László Dávid, Sayed-Amir Mara...