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BMCBI
2006
161views more  BMCBI 2006»
15 years 3 months ago
A method for rapid similarity analysis of RNA secondary structures
Background: Owing to the rapid expansion of RNA structure databases in recent years, efficient methods for structure comparison are in demand for function prediction and evolution...
Na Liu, Tianming Wang
BMCBI
2005
97views more  BMCBI 2005»
15 years 3 months ago
Comparative mapping of sequence-based and structure-based protein domains
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
Ya Zhang, John-Marc Chandonia, Chris H. Q. Ding, S...
BMCBI
2005
118views more  BMCBI 2005»
15 years 3 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2006
207views more  BMCBI 2006»
15 years 3 months ago
A new measure for functional similarity of gene products based on Gene Ontology
Background: Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods ...
Andreas Schlicker, Francisco S. Domingues, Jö...
ATAL
2005
Springer
15 years 8 months ago
Improving reinforcement learning function approximators via neuroevolution
Reinforcement learning problems are commonly tackled with temporal difference methods, which use dynamic programming and statistical sampling to estimate the long-term value of ta...
Shimon Whiteson