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BMCBI
2008
126views more  BMCBI 2008»
15 years 3 months ago
c-REDUCE: Incorporating sequence conservation to detect motifs that correlate with expression
Background: Computational methods for characterizing novel transcription factor binding sites search for sequence patterns or "motifs" that appear repeatedly in genomic ...
Katerina Kechris, Hao Li
BMCBI
2006
102views more  BMCBI 2006»
15 years 3 months ago
Protein secondary structure prediction for a single-sequence using hidden semi-Markov models
Background: The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algor...
Zafer Aydin, Yucel Altunbasak, Mark Borodovsky
BMCBI
2006
150views more  BMCBI 2006»
15 years 3 months ago
Protein structure similarity from principle component correlation analysis
Background: Owing to rapid expansion of protein structure databases in recent years, methods of structure comparison are becoming increasingly effective and important in revealing...
Xiaobo Zhou, James Chou, Stephen T. C. Wong
BMCBI
2005
162views more  BMCBI 2005»
15 years 3 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
JCB
2007
146views more  JCB 2007»
15 years 3 months ago
MSOAR: A High-Throughput Ortholog Assignment System Based on Genome Rearrangement
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving variou...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...