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» Evolutionary sequence analysis of complete eukaryote genomes
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NAR
1998
101views more  NAR 1998»
14 years 9 months ago
The PRINTS protein fingerprint database in its fifth year
PRINTS is a database of protein family ‘fingerprints’ offering a diagnostic resource for newly-determined sequences. By contrast with PROSITE, which uses single consensus expr...
Terri K. Attwood, Michael E. Beck, Darren R. Flowe...
STOC
2006
ACM
129views Algorithms» more  STOC 2006»
15 years 10 months ago
Optimal phylogenetic reconstruction
One of the major tasks of evolutionary biology is the reconstruction of phylogenetic trees from molecular data. The evolutionary model is given by a Markov chain on the true evolu...
Constantinos Daskalakis, Elchanan Mossel, Sé...
BMCBI
2011
14 years 1 months ago
In-silico prediction of disorder content using hybrid sequence representation
Background: Intrinsically disordered proteins play important roles in various cellular activities and their prevalence was implicated in a number of human diseases. The knowledge ...
Marcin J. Mizianty, Tuo Zhang, Bin Xue, Yaoqi Zhou...
BMCBI
2010
177views more  BMCBI 2010»
14 years 10 months ago
Modular composition predicts kinase/substrate interactions
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
Yichuan Liu, Aydin Tozeren
BMCBI
2005
108views more  BMCBI 2005»
14 years 9 months ago
SplitTester: software to identify domains responsible for functional divergence in protein family
Background: Many protein families have undergone functional divergence after gene duplications such that current subgroups of the family carry out overlapping but distinct biologi...
Xiang Gao, Kent Vander Velden, Daniel F. Voytas, X...