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» Evolving Better Multiple Sequence Alignments
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BMCBI
2007
117views more  BMCBI 2007»
14 years 9 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2006
85views more  BMCBI 2006»
14 years 9 months ago
On single and multiple models of protein families for the detection of remote sequence relationships
Background: The detection of relationships between a protein sequence of unknown function and a sequence whose function has been characterised enables the transfer of functional a...
James A. Casbon, Mansoor A. S. Saqi
RECOMB
2006
Springer
15 years 10 months ago
Phylogenetic Profiling of Insertions and Deletions in Vertebrate Genomes
Micro-indels are small insertion or deletion events (indels) that occur during genome evolution. The study of micro-indels is important, both in order to better understand the unde...
Sagi Snir, Lior Pachter
NAR
2007
121views more  NAR 2007»
14 years 9 months ago
WormBase: new content and better access
WormBase (http://wormbase.org), a model organism database for Caenorhabditis elegans and other related nematodes, continues to evolve and expand. Over the past year WormBase has a...
Tamberlyn Bieri, Darin Blasiar, Philip Ozersky, Ig...
BMCBI
2007
142views more  BMCBI 2007»
14 years 9 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...