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» Evolving genetic regulatory networks for systems biology
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BMCBI
2006
239views more  BMCBI 2006»
14 years 9 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
BMCBI
2007
143views more  BMCBI 2007»
14 years 9 months ago
Factor analysis for gene regulatory networks and transcription factor activity profiles
Background: Most existing algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription fact...
Iosifina Pournara, Lorenz Wernisch
BMCBI
2008
154views more  BMCBI 2008»
14 years 9 months ago
GeNESiS: gene network evolution simulation software
Background: There has been a lot of interest in recent years focusing on the modeling and simulation of Gene Regulatory Networks (GRNs). However, the evolutionary mechanisms that ...
Anton Kratz, Masaru Tomita, Arun Krishnan
GECCO
2007
Springer
182views Optimization» more  GECCO 2007»
15 years 1 months ago
Stochastic training of a biologically plausible spino-neuromuscular system model
A primary goal of evolutionary robotics is to create systems that are as robust and adaptive as the human body. Moving toward this goal often involves training control systems tha...
Stanley Phillips Gotshall, Terence Soule
BMCBI
2010
160views more  BMCBI 2010»
14 years 9 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian