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BMCBI
2006
145views more  BMCBI 2006»
14 years 9 months ago
Fast-Find: A novel computational approach to analyzing combinatorial motifs
Background: Many vital biological processes, including transcription and splicing, require a combination of short, degenerate sequence patterns, or motifs, adjacent to defined seq...
Micah Hamady, Erin Peden, Rob Knight, Ravinder Sin...
BMCBI
2006
147views more  BMCBI 2006»
14 years 9 months ago
Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data
Background: Gene Ontology (GO) terms are often used to assess the results of microarray experiments. The most common way to do this is to perform Fisher's exact tests to find...
Alex Lewin, Ian C. Grieve
BMCBI
2006
131views more  BMCBI 2006»
14 years 9 months ago
Hybridization interactions between probesets in short oligo microarrays lead to spurious correlations
Background: Microarrays measure the binding of nucleotide sequences to a set of sequence specific probes. This information is combined with annotation specifying the relationship ...
Michal J. Okoniewski, Crispin J. Miller
BMCBI
2006
127views more  BMCBI 2006»
14 years 9 months ago
Using local gene expression similarities to discover regulatory binding site modules
Background: We present an approach designed to identify gene regulation patterns using sequence and expression data collected for Saccharomyces cerevisae. Our main goal is to rela...
Bartek Wilczynski, Torgeir R. Hvidsten, Andriy Kry...
BMCBI
2007
115views more  BMCBI 2007»
14 years 9 months ago
A novel, fast, HMM-with-Duration implementation - for application with a new, pattern recognition informed, nanopore detector
Background: Hidden Markov Models (HMMs) provide an excellent means for structure identification and feature extraction on stochastic sequential data. An HMM-with-Duration (HMMwD) ...
Stephen Winters-Hilt, Carl Baribault