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161
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BMCBI
2008
15 years 5 months ago
2008
Background: The expressed sequence tag (EST) methodology is an attractive option for the generation of sequence data for species for which no completely sequenced genome is availa...
160
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BMCBI
2008
15 years 5 months ago
2008
Background: Previous studies comparing quantitative proteomics and microarray data have generally found poor correspondence between the two. We hypothesised that this might in par...
149
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BMCBI
2008
15 years 5 months ago
2008
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
161
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BMCBI
2010
15 years 5 months ago
2010
Background: Recent biological discoveries have shown that clustering large datasets is essential for better understanding biology in many areas. Spectral clustering in particular ...
162
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BMCBI
2008
15 years 5 months ago
2008
Background: Large biological data sets, such as expression profiles, benefit from reduction of random noise. Principal component (PC) analysis has been used for this purpose, but ...