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BMCBI
2008
129views more  BMCBI 2008»
14 years 11 months ago
A unified approach to false discovery rate estimation
Background: False discovery rate (FDR) methods play an important role in analyzing highdimensional data. There are two types of FDR, tail area-based FDR and local FDR, as well as ...
Korbinian Strimmer
HIPC
2009
Springer
14 years 8 months ago
Comparing the performance of clusters, Hadoop, and Active Disks on microarray correlation computations
Abstract--Microarray-based comparative genomic hybridization (aCGH) offers an increasingly fine-grained method for detecting copy number variations in DNA. These copy number variat...
Jeffrey A. Delmerico, Nathanial A. Byrnes, Andrew ...
AIPS
2003
15 years 14 days ago
A Multi-Agent System-driven AI Planning Approach to Biological Pathway Discovery
As genomic and proteomic data is collected from highthroughput methods on a daily basis, subcellular components are identified and their in vitro behavior is characterized. Howev...
Salim Khan, William Gillis, Carl Schmidt, Keith De...
BMCBI
2010
113views more  BMCBI 2010»
14 years 11 months ago
Improving performance of mammalian microRNA target prediction
Background: MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA...
Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao, Yu...
APBC
2004
122views Bioinformatics» more  APBC 2004»
15 years 14 days ago
Evolution of Relative Synonymous Codon Usage in Human Immunodeficiency Virus Type 1
Mutation in HIV-1 is extremely rapid, a consequence of a low-fidelity viral reverse transcription process. The envelope gene has been shown to accumulate substitutions at a rate o...
Peter L. Meintjes, Allen G. Rodrigo