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EVOW
2007
Springer
15 years 5 months ago
Bio-mimetic Evolutionary Reverse Engineering of Genetic Regulatory Networks
The effective reverse engineering of biochemical networks is one of the great challenges of systems biology. The contribution of this paper is two-fold: 1) We introduce a new meth...
Daniel Marbach, Claudio Mattiussi, Dario Floreano
BMCBI
2005
178views more  BMCBI 2005»
14 years 11 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...
BMCBI
2007
197views more  BMCBI 2007»
14 years 11 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park
JMLR
2006
103views more  JMLR 2006»
14 years 11 months ago
MinReg: A Scalable Algorithm for Learning Parsimonious Regulatory Networks in Yeast and Mammals
In recent years, there has been a growing interest in applying Bayesian networks and their extensions to reconstruct regulatory networks from gene expression data. Since the gene ...
Dana Pe'er, Amos Tanay, Aviv Regev
BMCBI
2006
202views more  BMCBI 2006»
14 years 11 months ago
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks
Background: The learning of global genetic regulatory networks from expression data is a severely under-constrained problem that is aided by reducing the dimensionality of the sea...
David J. Reiss, Nitin S. Baliga, Richard Bonneau