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104
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BMCBI
2007
166views more  BMCBI 2007»
14 years 12 months ago
Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics
Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of pepti...
Xinning Jiang, Xiaogang Jiang, Guanghui Han, Mingl...
BMCBI
2005
115views more  BMCBI 2005»
14 years 11 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
102
Voted
BMCBI
2006
159views more  BMCBI 2006»
14 years 11 months ago
MultiSeq: unifying sequence and structure data for evolutionary analysis
Background: Since the publication of the first draft of the human genome in 2000, bioinformatic data have been accumulating at an overwhelming pace. Currently, more than 3 million...
Elijah Roberts, John Eargle, Dan Wright, Zaida Lut...
BMCBI
2006
143views more  BMCBI 2006»
14 years 11 months ago
IsoSVM - Distinguishing isoforms and paralogs on the protein level
Background: Recent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred...
Michael Spitzer, Stefan Lorkowski, Paul Cullen, Al...
BMCBI
2004
119views more  BMCBI 2004»
14 years 11 months ago
Genome SEGE: A database for 'intronless' genes in eukaryotic genomes
Background: A number of completely sequenced eukaryotic genome data are available in the public domain. Eukaryotic genes are either 'intron containing' or 'intronle...
Meena K. Sakharkar, Pandjassarame Kangueane