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110
Voted
BMCBI
2008
15 years 19 days ago
2008
Background: Enzymes are responsible for the catalysis of the biochemical reactions in metabolic pathways. Analogous enzymes are able to catalyze the same reactions, but they prese...
142
Voted
BMCBI
2011
14 years 7 months ago
2011
Background: In the last decades, microarray technology has spread, leading to a dramatic increase of publicly available datasets. The first statistical tools developed were focuse...
104
Voted
BMCBI
2008
15 years 19 days ago
2008
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
129
Voted
RECOMB
2010
Springer
15 years 2 months ago
2010
Springer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
BMCBI
2007
15 years 19 days ago
2007
Background: Identification of the structural domains of proteins is important for our understanding of the organizational principles and mechanisms of protein folding, and for ins...