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BMCBI
2011
14 years 3 months ago
Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence
Background: Alternative splicing of pre-mature RNA is an important process eukaryotes utilize to increase their repertoire of different protein products. Several types of differen...
Holger Pillmann, Klas Hatje, Florian Odronitz, Bjo...
BMCBI
2011
14 years 3 months ago
SeqGene: a comprehensive software solution for mining exome- and transcriptome- sequencing data
Background: The popularity of massively parallel exome and transcriptome sequencing projects demands new data mining tools with a comprehensive set of features to support a wide r...
Xutao Deng
JAMIA
2011
98views more  JAMIA 2011»
14 years 2 months ago
Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network
Background Systematic study of clinical phenotypes is important for a better understanding of the genetic basis of human diseases and more effective gene-based disease management....
Jyotishman Pathak, Janey Wang, Sudha Kashyap, Meli...
SIGMOD
2012
ACM
288views Database» more  SIGMOD 2012»
13 years 2 months ago
Exploiting MapReduce-based similarity joins
Cloud enabled systems have become a crucial component to efficiently process and analyze massive amounts of data. One of the key data processing and analysis operations is the Sim...
Yasin N. Silva, Jason M. Reed
BMCBI
2007
104views more  BMCBI 2007»
14 years 12 months ago
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...