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RECOMB
2007
Springer
15 years 6 months ago
Nucleosome Occupancy Information Improves de novo Motif Discovery
A complete understanding of transcriptional regulatory processes in the cell requires identification of transcription factor binding sites on a genomewide scale. Unfortunately, th...
Leelavati Narlikar, Raluca Gordân, Alexander...
DSRT
2008
IEEE
15 years 6 months ago
Simulation and Implementation of the PTIDES Programming Model
We have previously proposed PTIDES (Programming Temporally Integrated Distributed Embedded Systems), a discrete-event framework that binds realtime with model time at sensors, act...
Patricia Derler, Edward A. Lee, Slobodan Matic
VAMOS
2008
Springer
15 years 1 months ago
Model-Based Implementation of Meta-Variability Constructs: A Case Study using Aspects
In this paper, we introduce the concept of metavariability, i.e., variability with respect to basic variability attributes like binding time or constraints. While the main focus o...
Klaus Schmid, Holger Eichelberger
BMCBI
2010
106views more  BMCBI 2010»
15 years 3 hour ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron
BMCBI
2008
102views more  BMCBI 2008»
14 years 12 months ago
Stability of the core domain of p53: insights from computer simulations
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...
Arumugam Madhumalar, Derek John Smith, Chandra Ver...