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» Framework for a Protein Ontology
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BMCBI
2006
134views more  BMCBI 2006»
15 years 25 days ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
126
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PVLDB
2010
129views more  PVLDB 2010»
14 years 11 months ago
iGraph: A Framework for Comparisons of Disk-Based Graph Indexing Techniques
Graphs are of growing importance in modeling complex structures such as chemical compounds, proteins, images, and program dependence. Given a query graph Q, the subgraph isomorphi...
Wook-Shin Han, Jinsoo Lee, Minh-Duc Pham, Jeffrey ...
BMCBI
2007
130views more  BMCBI 2007»
15 years 27 days ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
SSDBM
2009
IEEE
166views Database» more  SSDBM 2009»
15 years 7 months ago
Design and Implementation of Metadata System in PetaShare
As the size of scientific and commercial datasets grows, it becomes imperative that an expressive metadata framework to be developed to facilitate access to the semantics of the d...
Xinqi Wang, Tevfik Kosar
98
Voted
BMCBI
2008
124views more  BMCBI 2008»
15 years 27 days ago
A relation based measure of semantic similarity for Gene Ontology annotations
Background: Various measures of semantic similarity of terms in bio-ontologies such as the Gene Ontology (GO) have been used to compare gene products. Such measures of similarity ...
Brendan Sheehan, Aaron J. Quigley, Benoit Gaudin, ...