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BMCBI
2010
116views more  BMCBI 2010»
14 years 9 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2007
94views more  BMCBI 2007»
14 years 9 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...
92
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NN
1998
Springer
151views Neural Networks» more  NN 1998»
14 years 9 months ago
Evolutionary neurocontrollers for autonomous mobile robots
In this article we describe a methodology for evolving neurocontrollers of autonomous mobile robots without human intervention. The presentation, which spans from technological an...
Dario Floreano, Francesco Mondada
82
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TNN
1998
125views more  TNN 1998»
14 years 9 months ago
Symbolic connectionism in natural language disambiguation
Abstract—Natural language understanding involves the simultaneous consideration of a large number of different sources of information. Traditional methods employed in language an...
Samuel W. K. Chan, James Franklin
MST
2007
122views more  MST 2007»
14 years 9 months ago
Rendezvous and Election of Mobile Agents: Impact of Sense of Direction
Consider a collection of r identical asynchronous mobile agents dispersed on an arbitrary anonymous network of size n. The agents all execute the same protocol and move from node ...
Lali Barrière, Paola Flocchini, Pierre Frai...