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BMCBI
2010
98views more  BMCBI 2010»
15 years 12 hour ago
Prediction of protein structural classes for low-homology sequences based on predicted secondary structure
Background: Prediction of protein structural classes (a, b, a + b and a/b) from amino acid sequences is of great importance, as it is beneficial to study protein function, regulat...
Jian-Yi Yang, Zhen-Ling Peng, Xin Chen
BMCBI
2008
174views more  BMCBI 2008»
15 years 11 hour ago
Evolutionary approaches for the reverse-engineering of gene regulatory networks: A study on a biologically realistic dataset
Background: Inferring gene regulatory networks from data requires the development of algorithms devoted to structure extraction. When only static data are available, gene interact...
Cédric Auliac, Vincent Frouin, Xavier Gidro...
BMCBI
2008
135views more  BMCBI 2008»
15 years 11 hour ago
Knowledge-guided multi-scale independent component analysis for biomarker identification
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
Li Chen, Jianhua Xuan, Chen Wang, Ie-Ming Shih, Yu...
BMCBI
2008
98views more  BMCBI 2008»
15 years 9 hour ago
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Background: Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aber...
Johan Staaf, Johan Vallon-Christersson, David Lind...
BMCBI
2006
90views more  BMCBI 2006»
14 years 12 months ago
The PowerAtlas: a power and sample size atlas for microarray experimental design and research
Background: Microarrays permit biologists to simultaneously measure the mRNA abundance of thousands of genes. An important issue facing investigators planning microarray experimen...
Grier P. Page, Jode W. Edwards, Gary L. Gadbury, P...