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» Functional Validation in Grid Computing
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101
Voted
BMCBI
2007
97views more  BMCBI 2007»
15 years 20 days ago
Relating destabilizing regions to known functional sites in proteins
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relative...
Benoit H. Dessailly, Marc F. Lensink, Shoshana J. ...
103
Voted
BMCBI
2007
116views more  BMCBI 2007»
15 years 17 days ago
Clustering protein environments for function prediction: finding PROSITE motifs in 3D
Background: Structural genomics initiatives are producing increasing numbers of threedimensional (3D) structures for which there is little functional information. Structure-based ...
Sungroh Yoon, Jessica C. Ebert, Eui-Young Chung, G...
BIBM
2009
IEEE
206views Bioinformatics» more  BIBM 2009»
15 years 7 months ago
Application of Kernel Functions for Accurate Similarity Search in Large Chemical Databases
Background: Similaritysearch in chemical structure databases is an important problem with many applications in chemical genomics, drug design, and efficient chemical probe screeni...
Xiaohong Wang, Jun Huan, Aaron M. Smalter, Gerald ...
139
Voted
CSB
2005
IEEE
189views Bioinformatics» more  CSB 2005»
15 years 6 months ago
Learning Yeast Gene Functions from Heterogeneous Sources of Data Using Hybrid Weighted Bayesian Networks
We developed a machine learning system for determining gene functions from heterogeneous sources of data sets using a Weighted Naive Bayesian Network (WNB). The knowledge of gene ...
Xutao Deng, Huimin Geng, Hesham H. Ali
102
Voted
BMCBI
2008
145views more  BMCBI 2008»
15 years 20 days ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...