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SAC
2009
ACM
15 years 4 months ago
Measuring coherence between electronic and manual annotations in biological databases
The use of controlled structured vocabularies for annotation purposes, such as the Gene Ontology (GO) is currently one of the strategies to cope with the increasingly cumbersome t...
Catia Pesquita, Daniel Faria, Francisco M. Couto
BMCBI
2007
94views more  BMCBI 2007»
14 years 10 months ago
False positive reduction in protein-protein interaction predictions using gene ontology annotations
Background: Many crucial cellular operations such as metabolism, signalling, and regulations are based on protein-protein interactions. However, the lack of robust protein-protein...
Mahmood A. Mahdavi, Yen-Han Lin
BMCBI
2008
127views more  BMCBI 2008»
14 years 10 months ago
Gene and pathway identification with Lp penalized Bayesian logistic regression
Background: Identifying genes and pathways associated with diseases such as cancer has been a subject of considerable research in recent years in the area of bioinformatics and co...
Zhenqiu Liu, Ronald B. Gartenhaus, Ming Tan, Feng ...
BMCBI
2008
110views more  BMCBI 2008»
14 years 10 months ago
Testing for treatment effects on gene ontology
In studies that use DNA arrays to assess changes in gene expression, it is preferable to measure the significance of treatment effects on a group of genes from a pathway or functi...
Taewon Lee, Varsha G. Desai, Cruz Velasco, Robert ...
BMCBI
2008
126views more  BMCBI 2008»
14 years 10 months ago
Relating gene expression data on two-component systems to functional annotations in Escherichia coli
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
Anne M. Denton, Jianfei Wu, Megan K. Townsend, Pre...