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RECOMB
2004
Springer
16 years 1 days ago
The Distribution of Inversion Lengths in Bacteria
The distribution of the lengths of genomic segments inverte during the evolutionary divergence of two species cannot be inferred d rectly from the output of genome rearrangement al...
Adrian Maler, David Sankoff, Elisabeth R. M. Tilli...
CPM
2004
Springer
107views Combinatorics» more  CPM 2004»
15 years 3 months ago
Sorting by Reversals in Subquadratic Time
The problem of sorting a signed permutation by reversals is inspired by genome rearrangements in computational molecular biology. Given two genomes represented as two signed permut...
Eric Tannier, Marie-France Sagot
BIBM
2010
IEEE
161views Bioinformatics» more  BIBM 2010»
14 years 9 months ago
Cis-regulatory module detection using constraint programming
We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same t...
Tias Guns, Hong Sun, Kathleen Marchal, Siegfried N...
BMCBI
2005
178views more  BMCBI 2005»
14 years 11 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...
BMCBI
2008
142views more  BMCBI 2008»
14 years 12 months ago
Microarray data mining: A novel optimization-based approach to uncover biologically coherent structures
Background: DNA microarray technology allows for the measurement of genome-wide expression patterns. Within the resultant mass of data lies the problem of analyzing and presenting...
Meng Piao Tan, Erin N. Smith, James R. Broach, Chr...