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» Gene prediction with a hidden Markov model and a new intron ...
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BMCBI
2005
108views more  BMCBI 2005»
13 years 6 months ago
A linear memory algorithm for Baum-Welch training
Background: Baum-Welch training is an expectation-maximisation algorithm for training the emission and transition probabilities of hidden Markov models in a fully automated way. I...
István Miklós, Irmtraud M. Meyer
BMCBI
2007
135views more  BMCBI 2007»
13 years 6 months ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
RECOMB
2004
Springer
14 years 6 months ago
Computational identification of evolutionarily conserved exons
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multispecies version of the ab initio gene prediction problem. These models ...
Adam C. Siepel, David Haussler
ISMB
2004
13 years 7 months ago
Exploiting conserved structure for faster annotation of non-coding RNAs without loss of accuracy
Motivation: Non-coding RNAs (ncRNAs)--functional RNA molecules not coding for proteins--are grouped into hundreds of families of homologs. To find new members of an ncRNA gene fam...
Zasha Weinberg, Walter L. Ruzzo