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BMCBI
2010
95views more  BMCBI 2010»
14 years 12 months ago
Spatio-structural granularity of biological material entities
Background: With the continuously increasing demands on knowledge- and data-management that databases have to meet, ontologies and the theories of granularity they use become more...
Lars Vogt
BMCBI
2010
126views more  BMCBI 2010»
14 years 12 months ago
A boosting method for maximizing the partial area under the ROC curve
Background: The receiver operating characteristic (ROC) curve is a fundamental tool to assess the discriminant performance for not only a single marker but also a score function c...
Osamu Komori, Shinto Eguchi
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BMCBI
2010
109views more  BMCBI 2010»
14 years 12 months ago
Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model
Background: The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a dist...
Andrew J. Bordner, Hans D. Mittelmann
BMCBI
2010
113views more  BMCBI 2010»
14 years 12 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
BMCBI
2010
144views more  BMCBI 2010»
14 years 12 months ago
Finding sRNA generative locales from high-throughput sequencing data with NiBLS
Background: Next-generation sequencing technologies allow researchers to obtain millions of sequence reads in a single experiment. One important use of the technology is the seque...
Daniel MacLean, Vincent Moulton, David J. Studholm...