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WABI
2010
Springer
143views Bioinformatics» more  WABI 2010»
15 years 1 months ago
Swiftly Computing Center Strings
The center string (or closest string) problem is a classical computer science problem with important applications in computational biology. Given k input strings and a distance thr...
Franziska Hufsky, Léon Kuchenbecker, Kathar...
WABI
2010
Springer
177views Bioinformatics» more  WABI 2010»
15 years 1 months ago
Estimation of Alternative Splicing isoform Frequencies from RNA-Seq Data
In this paper we present a novel expectation-maximization algorithm for inference of alternative splicing isoform frequencies from high-throughput transcriptome sequencing (RNA-Seq...
Marius Nicolae, Serghei Mangul, Ion I. Mandoiu, Al...
170
Voted
WABI
2010
Springer
160views Bioinformatics» more  WABI 2010»
15 years 1 months ago
Genomic Distance with DCJ and Indels
The double cut and join (DCJ) operation, introduced by Yancopoulos, Attie and Friedberg in 2005, allows one to represent most rearrangement events in genomes. However, a DCJ cannot...
Marília D. V. Braga, Eyla Willing, Jens Sto...
BIBM
2010
IEEE
161views Bioinformatics» more  BIBM 2010»
15 years 1 months ago
Cis-regulatory module detection using constraint programming
We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same t...
Tias Guns, Hong Sun, Kathleen Marchal, Siegfried N...
169
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BIOCOMP
2010
15 years 1 months ago
Extraction of Protein Sequence Motifs Information by Bi-Clustering Algorithm
- The activities and function of proteins can potentially be determined by protein sequence motifs. Therefore, obtaining the universally conserved and crossed protein family bounda...
Vincent Yip, Bernard Chen, Sinan Kockara