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BMCBI
2005
123views more  BMCBI 2005»
15 years 4 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas
BMCBI
2005
118views more  BMCBI 2005»
15 years 4 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2005
97views more  BMCBI 2005»
15 years 4 months ago
Phylogenetic reconstruction of ancestral character states for gene expression and mRNA splicing data
Background: As genomes evolve after speciation, gene content, coding sequence, gene expression, and splicing all diverge with time from ancestors with close relatives. A minimum e...
Roald Rossnes, Ingvar Eidhammer, David A. Liberles
TSP
2008
179views more  TSP 2008»
15 years 4 months ago
Estimation in Gaussian Graphical Models Using Tractable Subgraphs: A Walk-Sum Analysis
Graphical models provide a powerful formalism for statistical signal processing. Due to their sophisticated modeling capabilities, they have found applications in a variety of fie...
V. Chandrasekaran, Jason K. Johnson, Alan S. Wills...
BMCBI
2004
135views more  BMCBI 2004»
15 years 4 months ago
Determination of the differentially expressed genes in microarray experiments using local FDR
Background: Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expect...
Julie Aubert, Avner Bar-Hen, Jean-Jacques Daudin, ...
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