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CSB
2004
IEEE
112views Bioinformatics» more  CSB 2004»
15 years 10 months ago
Reasoning about Molecular Similarity and Properties
Ascertaining the similarity amongst molecules is a fundamental problem in biology and drug discovery. Since similar molecules tend to have similar biological properties, the notio...
Rahul Singh
BIBE
2001
IEEE
15 years 10 months ago
Gene Classification using Expression Profiles: A Feasibility Study
As various genome sequencing projects have already been completed or are near completion, genome researchers are shifting their focus from structural genomics to functional genomi...
Michihiro Kuramochi, George Karypis
BMCBI
2010
130views more  BMCBI 2010»
15 years 6 months ago
The behaviour of random forest permutation-based variable importance measures under predictor correlation
Background: Random forests (RF) have been increasingly used in applications such as genome-wide association and microarray studies where predictor correlation is frequently observ...
Kristin K. Nicodemus, James D. Malley, Carolin Str...
BMCBI
2010
84views more  BMCBI 2010»
15 years 6 months ago
Testing the additional predictive value of high-dimensional molecular data
Background: While high-dimensional molecular data such as microarray gene expression data have been used for disease outcome prediction or diagnosis purposes for about ten years i...
Anne-Laure Boulesteix, Torsten Hothorn
BMCBI
2010
167views more  BMCBI 2010»
15 years 6 months ago
Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of met
Background: Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment. While these lists represent an accurat...
Melissa J. Morine, Jolene McMonagle, Sinead Toomey...