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BMCBI
2007
172views more  BMCBI 2007»
14 years 9 months ago
Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks
Background: Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly su...
Fulvia Ferrazzi, Paola Sebastiani, Marco Ramoni, R...
SISAP
2010
IEEE
135views Data Mining» more  SISAP 2010»
14 years 8 months ago
Improving the similarity search of tandem mass spectra using metric access methods
In biological applications, the tandem mass spectrometry is a widely used method for determining protein and peptide sequences from an ”in vitro” sample. The sequences are not...
Jiri Novák, Tomás Skopal, David Hoks...
NAR
1998
112views more  NAR 1998»
14 years 9 months ago
MITOMAP: a human mitochondrial genome database--1998 update
We have continued to develop MITOMAP (http://www.gen.emory.edu/MITOMAP ), a comprehensive database for the human mitochondrial DNA (mtDNA). MITOMAP uses the mtDNA sequence as the ...
Andreas M. Kogelnik, Marie T. Lott, Michael D. Bro...
BCB
2010
140views Bioinformatics» more  BCB 2010»
14 years 4 months ago
Guiding belief propagation using domain knowledge for protein-structure determination
A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
Ameet Soni, Craig A. Bingman, Jude W. Shavlik
BMCBI
2006
120views more  BMCBI 2006»
14 years 10 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner