The Internet makes it possible to share and manipulate a vast quantity of information efficiently and effectively, but the rapid and chaotic growth experienced by the Net has gener...
Background: Clustering the information content of large high-dimensional gene expression datasets has widespread application in "omics" biology. Unfortunately, the under...
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...