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130
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ISDA
2006
IEEE
15 years 9 months ago
From Gene to Drug: A Proof of Concept for a Plausible Computational Pathway
The last decade has witnessed an exponential growth of sequence information in the field of biological macromolecules such as proteins and nucleic acids and their interactions wit...
Sandhya Shenoy, B. Jayaram, N. Latha, Pooja Narang...
122
Voted
CSB
2004
IEEE
115views Bioinformatics» more  CSB 2004»
15 years 7 months ago
PoPS: A Computational Tool for Modeling and Predicting Protease Specificity
Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremel...
Sarah E. Boyd, Maria J. García de la Banda,...
138
Voted
CSB
2005
IEEE
136views Bioinformatics» more  CSB 2005»
15 years 9 months ago
An Algebraic Geometry Approach to Protein Structure Determination from NMR Data
Our paper describes the first provably-efficient algorithm for determining protein structures de novo, solely from experimental data. We show how the global nature of a certain ...
Lincong Wang, Ramgopal R. Mettu, Bruce Randall Don...
SDM
2008
SIAM
119views Data Mining» more  SDM 2008»
15 years 4 months ago
An Efficient Local Algorithm for Distributed Multivariate Regression in Peer-to-Peer Networks
This paper offers a local distributed algorithm for multivariate regression in large peer-to-peer environments. The algorithm is designed for distributed inferencing, data compact...
Kanishka Bhaduri, Hillol Kargupta
142
Voted
AINA
2006
IEEE
15 years 9 months ago
Partitioned optimization algorithms for multiple sequence alignment
Multiple sequence alignment is an important and difficult problem in molecular biology and bioinformatics. In this paper, we propose a partitioning approach that significantly impr...
Yixin Chen, Yi Pan, Juan Chen, Wei Liu, Ling Chen