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BICOB
2009
Springer
15 years 6 months ago
Assembly of Large Genomes from Paired Short Reads
The de novo assembly of genomes from high-throughput short reads is an active area of research. Several promising methods have been recently developed, with applicability mainly re...
Benjamin G. Jackson, Patrick S. Schnable, Srinivas...
ISBRA
2009
Springer
15 years 6 months ago
Untangling Tanglegrams: Comparing Trees by Their Drawings
A tanglegram is a pair of trees on the same set of leaves with matching leaves in the two trees joined by an edge. Tanglegrams are widely used in biology – to compare evolutiona...
Balaji Venkatachalam, Jim Apple, Katherine St. Joh...
UAI
2008
15 years 1 months ago
Discovering Cyclic Causal Models by Independent Components Analysis
We generalize Shimizu et al's (2006) ICA-based approach for discovering linear non-Gaussian acyclic (LiNGAM) Structural Equation Models (SEMs) from causally sufficient, conti...
Gustavo Lacerda, Peter Spirtes, Joseph Ramsey, Pat...
BMCBI
2010
119views more  BMCBI 2010»
14 years 12 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
BMCBI
2006
123views more  BMCBI 2006»
14 years 12 months ago
Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...