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BMCBI
2005
115views more  BMCBI 2005»
14 years 9 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
89
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BMCBI
2006
161views more  BMCBI 2006»
14 years 9 months ago
A novel approach to phylogenetic tree construction using stochastic optimization and clustering
Background: The problem of inferring the evolutionary history and constructing the phylogenetic tree with high performance has become one of the major problems in computational bi...
Ling Qin, Yixin Chen, Yi Pan, Ling Chen
BMCBI
2007
93views more  BMCBI 2007»
14 years 9 months ago
The topology of metabolic isotope labeling networks
Background: Metabolic Flux Analysis (MFA) based on isotope labeling experiments (ILEs) is a widely established tool for determining fluxes in metabolic pathways. Isotope labeling ...
Michael Weitzel, Wolfgang Wiechert, Katharina N&ou...
BMCBI
2007
109views more  BMCBI 2007»
14 years 9 months ago
A domain-based approach to predict protein-protein interactions
Background: Knowing which proteins exist in a certain organism or cell type and how these proteins interact with each other are necessary for the understanding of biological proce...
Mudita Singhal, Haluk Resat
78
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BMCBI
2006
118views more  BMCBI 2006»
14 years 9 months ago
A graphical model approach to automated classification of protein subcellular location patterns in multi-cell images
Background: Knowledge of the subcellular location of a protein is critical to understanding how that protein works in a cell. This location is frequently determined by the interpr...
Shann-Ching Chen, Robert F. Murphy