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BMCBI
2011
14 years 11 months ago
PileLine: a toolbox to handle genome position information in next-generation sequencing studies
Background: Genomic position (GP) files currently used in next-generation sequencing (NGS) studies are always difficult to manipulate due to their huge size and the lack of approp...
Daniel Glez-Peña, Gonzalo Gómez-L&oa...
BMCBI
2011
14 years 8 months ago
A fast and accurate method to detect allelic genomic imbalances underlying mosaic rearrangements using SNP array data
Background: Mosaicism for copy number and copy neutral chromosomal rearrangements has been recently identified as a relatively common source of genetic variation in the normal pop...
Juan R. González, Benjamin Rodriguez-Santia...
STOC
2012
ACM
209views Algorithms» more  STOC 2012»
13 years 6 months ago
Nearly optimal solutions for the chow parameters problem and low-weight approximation of halfspaces
The Chow parameters of a Boolean function f : {−1, 1}n → {−1, 1} are its n + 1 degree-0 and degree-1 Fourier coefficients. It has been known since 1961 [Cho61, Tan61] that ...
Anindya De, Ilias Diakonikolas, Vitaly Feldman, Ro...
BMCBI
2007
226views more  BMCBI 2007»
15 years 4 months ago
MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans
Background: MicroRNAs (miRNAs) are recognized as one of the most important families of noncoding RNAs that serve as important sequence-specific post-transcriptional regulators of ...
Ting-Hua Huang, Bin Fan, Max F. Rothschild, Zhi-Li...
BMCBI
2006
107views more  BMCBI 2006»
15 years 4 months ago
A reinforced merging methodology for mapping unique peptide motifs in members of protein families
Background: Members of a protein family often have highly conserved sequences; most of these sequences carry identical biological functions and possess similar three-dimensional (...
Hao-Teng Chang, Tun-Wen Pai, Tan-Chi Fan, Bo-Han S...