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BMCBI
2006
142views more  BMCBI 2006»
15 years 3 months ago
PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
Background: We present a general approach to perform association analyses in pedigrees of arbitrary size and structure, which also allows for a mixture of pedigree members and ind...
Kristina Allen-Brady, Jathine Wong, Nicola J. Camp
BMCBI
2006
169views more  BMCBI 2006»
15 years 3 months ago
Comparative analysis of haplotype association mapping algorithms
Background: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross b...
Phillip McClurg, Mathew T. Pletcher, Tim Wiltshire...
BMCBI
2006
161views more  BMCBI 2006»
15 years 3 months ago
A novel approach to phylogenetic tree construction using stochastic optimization and clustering
Background: The problem of inferring the evolutionary history and constructing the phylogenetic tree with high performance has become one of the major problems in computational bi...
Ling Qin, Yixin Chen, Yi Pan, Ling Chen
137
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BMCBI
2006
134views more  BMCBI 2006»
15 years 3 months ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
120
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BMCBI
2006
104views more  BMCBI 2006»
15 years 3 months ago
MANET: tracing evolution of protein architecture in metabolic networks
Background: Cellular metabolism can be characterized by networks of enzymatic reactions and transport processes capable of supporting cellular life. Our aim is to find evolutionar...
Hee Shin Kim, Jay E. Mittenthal, Gustavo Caetano-A...