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93
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BMCBI
2006
85views more  BMCBI 2006»
15 years 20 days ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen
119
Voted
BMCBI
2006
130views more  BMCBI 2006»
15 years 20 days ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
110
Voted
BMCBI
2006
103views more  BMCBI 2006»
15 years 20 days ago
Meta-All: a system for managing metabolic pathway information
Background: Many attempts are being made to understand biological subjects at a systems level. A major resource for these approaches are biological databases, storing manifold inf...
Stephan Weise, Ivo Grosse, Christian Klukas, Dirk ...
95
Voted
BMCBI
2006
150views more  BMCBI 2006»
15 years 20 days ago
Cluster analysis of protein array results via similarity of Gene Ontology annotation
Background: With the advent of high-throughput proteomic experiments such as arrays of purified proteins comes the need to analyse sets of proteins as an ensemble, as opposed to t...
Cheryl Wolting, C. Jane McGlade, David Tritchler
93
Voted
CACM
2006
102views more  CACM 2006»
15 years 20 days ago
Infoglut
whose titles and abstracts sound very interesting, the pile of unread reports continues to grow on the table in my office." (How quaint the terminology: mail and electronic me...
Peter J. Denning