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ASE
2006
15 years 2 months ago
2006
Commercial-off-the-shelf (COTS) software tends to be cheap, reliable, and functionally powerful due to its large user base. It has thus become highly desirable to incorporate COTS ...
118
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BMCBI
2006
15 years 2 months ago
2006
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
138
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BMCBI
2006
15 years 2 months ago
2006
Background: DNA copy number alterations are one of the main characteristics of the cancer cell karyotype and can contribute to the complex phenotype of these cells. These alterati...
136
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BMCBI
2006
15 years 2 months ago
2006
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
104
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BMCBI
2006
2006
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
15 years 2 months ago
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...