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BMCBI
2010
124views more  BMCBI 2010»
14 years 10 months ago
A factor model to analyze heterogeneity in gene expression
Background: Microarray technology allows the simultaneous analysis of thousands of genes within a single experiment. Significance analyses of transcriptomic data ignore the gene d...
Yuna Blum, Guillaume Le Mignon, Sandrine Lagarrigu...
CORR
2010
Springer
117views Education» more  CORR 2010»
14 years 10 months ago
Evolution with Drifting Targets
We consider the question of the stability of evolutionary algorithms to gradual changes, or drift, in the target concept. We define an algorithm to be resistant to drift if, for s...
Varun Kanade, Leslie G. Valiant, Jennifer Wortman ...
JCB
2008
106views more  JCB 2008»
14 years 10 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin
CORR
2007
Springer
91views Education» more  CORR 2007»
14 years 10 months ago
Unequal dimensional small balls and quantization on Grassmann Manifolds
—The Grassmann manifold Gn,p (L) is the set of all p-dimensional planes (through the origin) in the n-dimensional Euclidean space Ln , where L is either R or C. This paper consid...
Wei Dai, Brian Rider, Youjian Liu
BMCBI
2004
146views more  BMCBI 2004»
14 years 10 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker