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RECOMB
2009
Springer
15 years 7 months ago
Protein Fragment Swapping: A Method for Asymmetric, Selective Site-Directed Recombination
This paper presents a new approach to site-directed recombination, swapping combinations of selected discontiguous fragments from a source protein in place of corresponding fragmen...
Wei Zheng, Karl E. Griswold, Chris Bailey-Kellogg
GECCO
2004
Springer
164views Optimization» more  GECCO 2004»
15 years 5 months ago
Fuzzy Dominance Based Multi-objective GA-Simplex Hybrid Algorithms Applied to Gene Network Models
Hybrid algorithms that combine genetic algorithms with the Nelder-Mead simplex algorithm have been effective in solving certain optimization problems. In this article, we apply a s...
Praveen Koduru, Sanjoy Das, Stephen Welch, Judith ...
111
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ICML
2001
IEEE
16 years 1 months ago
Feature selection for high-dimensional genomic microarray data
We report on the successful application of feature selection methods to a classification problem in molecular biology involving only 72 data points in a 7130 dimensional space. Ou...
Eric P. Xing, Michael I. Jordan, Richard M. Karp
104
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ICAPR
2005
Springer
15 years 6 months ago
Hierarchical Clustering of Dynamical Systems Based on Eigenvalue Constraints
Abstract. This paper addresses the clustering problem of hidden dynamical systems behind observed multivariate sequences by assuming an interval-based temporal structure in the seq...
Hiroaki Kawashima, Takashi Matsuyama
BMCBI
2006
122views more  BMCBI 2006»
15 years 15 days ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...