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BMCBI
2010
181views more  BMCBI 2010»
13 years 6 months ago
Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes
Background: In many microarray experiments, analysis is severely hindered by a major difficulty: the small number of samples for which expression data has been measured. When one ...
Amit Zeisel, Amnon Amir, Wolfgang J. Köstler,...
BIBE
2007
IEEE
129views Bioinformatics» more  BIBE 2007»
13 years 10 months ago
Statistial Analysis of nucleosome occupancy and histone modification data
Abstract-- In eukaryotic cells, genomic DNAs wrap around beadlike molecules, called nucleosomes, so as to pack more compactly in the nucleus of the cell. The nucleosome is made up ...
Guo-Cheng Yuan, Jun S. Liu
BMCBI
2008
93views more  BMCBI 2008»
13 years 6 months ago
MPDA: Microarray pooled DNA analyzer
Background: Microarray-based pooled DNA experiments that combine the merits of DNA pooling and gene chip technology constitute a pivotal advance in biotechnology. This new techniq...
Hsin-Chou Yang, Mei-Chu Huang, Ling-Hui Li, Chien-...
BMCBI
2007
141views more  BMCBI 2007»
13 years 6 months ago
A novel approach to detect hot-spots in large-scale multivariate data
Background: Progressive advances in the measurement of complex multifactorial components of biological processes involving both spatial and temporal domains have made it difficult...
Jianhua Wu, Keith M. Kendrick, Jianfeng Feng
BMCBI
2011
13 years 23 days ago
Sequential Interim Analyses of Survival Data in DNA Microarray Experiments
Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Freq...
Andreas Leha, Tim Beißbarth, Klaus Jung